In patients with severe forms of COVID-19, an overactivation of the immune system and decrease of mediator (such as ACE2) activity causes excessive pro-inflammatory cytokine release (e.g. IL-6, -2, -10, -22, -1β, TNF-α, interferon γ, granulocyte-colony stimulating factor), known as the “cytokine storm” which leads to a deleterious local and systemic inflammatory response and subsequent multiple organ failure [30,31]. This evidence concerns the gene TNF and COVID-19.