SCARB1 and atherosclerosis: Vergeer M. et al. re-sequenced SCARB1 genes in subjects with high HDL-C levels (>70.4 mg/dl to 1.8 mmol/L) and identified a family carrying the missense mutation P297S, which co-segregated with high HDL-C levels, decreased the cholesterol efflux from macrophages, increased platelet dysfunction, and reduced adrenal steroidogenesis [94], although without significant impact on atherosclerosis [94].