FLNA and myocardial infarction: Mice that are deficient in FLNA in endothelial cells, by using Cre expression driven by the vascular endothelial-cadherin promoter show no abnormalities in vasculature or heart pump function, but, when myocardial infarction (MI) is induced in these mice, the endothelial cells in FLNA-deficient mice fail to generate new blood vessels, which results in larger scar areas after MI [44].