Furthermore, we also found that the combination of both polymorphisms of the TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a higher femoral neck BMD T-score in female subjects than in any other group, which means these genotypes had a potential to act as a predictive factor for postmenopausal osteoporosis in Taiwanese women. This evidence concerns the gene TGFB1 and postmenopausal osteoporosis.