This study is the first report to evaluate the risks of osteoporosis and the associations between the anti-inflammatory cytokine-specific SNPs—TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A)—and adjusted age, habitual Ca intake, gender, BMI and height in Taiwanese subjects; it showed a significantly lower total hip BMD when compared with other SNP combinations. The gene discussed is TGFB1; the disease is osteoporosis.