The femoral neck T-score of female subjects with both polymorphisms of the TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes was 1.1666 higher than those in any other group (p < 0.05), which means these genotypes had a greater tendency to prevent osteoporosis. This evidence concerns the gene TGFB1 and osteoporosis.