Protease asparaginyl endopeptidase (AEP), expressed in several carcinomas and previously associated with increased metastases and MMP activity, was shown to be transferred via PDA tumor cells derived-EVs and consequently, in recipient PDA tumor cells, increased migratory and invasive capacity, going along with the finding that AEP is usually found at the invasive front of tumors [46]. This evidence concerns the gene LGMN and Patent ductus arteriosus.