Indeed, several studies reported that highly metastatic PDA tumor cells-derived EVs are able to transfer metastatic potential to recipient cells, promoting migration and invasion, as shown by Jin et al. through the transfer of EVs containing zinc finger protein 4 [43] or by Wei et al. through the transfer of EVs carrying the receptor tyrosine kinase Eph receptor A2 (EphA2) [44]. This evidence concerns the gene EPHA2 and Patent ductus arteriosus.