AKT1 and Patent ductus arteriosus: Using synthetic nanoparticles with the same lipid composition as PDA cell-derived exosomes, Beloribi et al. demonstrated that MiaPaCa-2 cells resist gemcitabine’s anti-proliferative effects via SDF-1a secretion induced by lipids of nanoparticles, ultimately activating the Akt survival pathway passing through the CXCR4-SDF-1a axis [49].