Moreover, PC-derived EVs containing miR-27, identified as an oncogene in many cancers, cocultured with human microvascular endothelial cells (HMVECs) led to the upregulation of VEGF and increased proliferation and microvessel density through its action on downregulating the expression of a tumor suppressor, B-cell translocation gene-2 (BTG2) [103,104]. The gene discussed is BTG2; the disease is cancer.