Mutant p53, with the influence of Rab35, restrain the secretion of podocalyxin (PODXL) in EVs, and thus promote increased alpha-5-beta-1 integrin recycling in CAFs along with increased migration and the deposition of more branched, disorganized ECM fibers in both the pancreas and the lung, a primary site of PDA tumor metastases. This evidence concerns the gene TP53 and Patent ductus arteriosus.