TGFB1 and neoplasm: Tumor cell-derived EVs from various solid tumor types, containing TGFb1 tethered by surface betaglycan, cause the emergence of a myofibroblast phenotype with a rearrangement of the cytoskeleton to a-SMA-abundant and also increases FGF2 secretion, associated with stromal pro-tumoral activity, likely caused by TGFB1 and other factors found in EVs [64].