Organ selection by EVs may be due to selective integrin expression, as was found in a large proteomics study of primary malignant PDA tumor cells derived-EVs content, revealing integrin beta-5 and differential integrin beta-4 expression for liver and lung organotropism, respectively, as well as the upregulation of pro-metastatic proteins such as annexin-A1, MET and S100A4 [149]. The gene discussed is ITGB4; the disease is neoplasm.