ACTA1 and Patent ductus arteriosus: It was recently highlighted that CAFs, which were classified primarily as pro- or anti-tumoral, are in fact a mixture of many subtypes clustered depending on their expression of cell marker expressions such as α-SMA, PDGFR-β, fibroblast-associated protein (FAP) and podoplanin, among others or functional properties (inflammatory, antigen-presenting) and proportions of which vary within and between PDA tumors.