CD44v6 and Tspan8-carrying PDA tumor cells derived-EVs, when received by CD44v6 depleted non-metastatic cells, led to interactions of both molecules with Tspan8-associated integrins, CD49f and CD104, concomitant activation of mutual downstream pathways and conferred an adhesive, invasive and migratory phenotype to non-CIC [40]. Here, TSPAN8 is linked to neoplasm.