Circ-IARS acts as a sequester of tumor suppressor miR-122 and, via the RhoA pathway, is able to increase F-actin expression and cell contractility as well as a loss of tight junction protein zona-occludens-1 (ZO-1) in HUVECs, enhancing endothelial cell permeability and allowing for passage of tumor cells between cells [89]. The gene discussed is TJP1; the disease is neoplasm.