The expression of DDX46 is upregulated in colorectal carcinoma, esophageal squamous cell carcinoma, gastric cancer, and osteosarcoma cells, and knockdown of DDX46 inhibits cancer cell proliferation, invasion and induces cell apoptosis (Table 1) [78,79,80,81]. This evidence concerns the gene DDX46 and esophageal squamous cell carcinoma.