Depletion of the DDX56 arrest cell cycle in the G2/M phase via the decrease of tumor suppressor WEE1 expression, which functions as a G2/M DNA damage checkpoint (Figure 3) [94], results in the inhibition of cell proliferation and clone formation and the induction of p53 mediated apoptosis in osteosarcoma cells [92,93]. This evidence concerns the gene DDX56 and osteosarcoma.