We have used qPCR to compare YTHDF2 and YTHDC2 (m6A readers) transcript levels in cancerous and paired-matched histopathologically unchanged tissues from 45 patients with HNSCC and in 4 cell lines (FaDu, Detroit 562, A-253, SCC-15). This evidence concerns the gene YTHDC2 and head and neck squamous cell carcinoma.