Thus, we have also measured the mRNA level of selected RNA methylation-related genes (METTL3, FTO, YTHDF2, and YTHDC2), which were noticed to significantly affect the tumorigenesis process, and we have determined their correlation with m6A status and HNSCC patients’ clinical features and overall survival. This evidence concerns the gene YTHDF2 and head and neck squamous cell carcinoma.