We have used qPCR to determine the METTL3 (methyltransferase) and FTO (demethylase) transcript levels in cancerous and paired-matched histopathologically unchanged tissues from 45 patients with HNSCC and in 4 cell lines (FaDu, Detroit 562, A-253, SCC-15). Here, METTL3 is linked to head and neck squamous cell carcinoma.