CRBN and Miyoshi myopathy: Nevertheless, given the complexity of the molecular mechanisms involved in sensitivity or resistance to IMiD-based therapy, the predictive and prognostic role of the CLR4–CRBN complex cannot be reliably established without a comprehensive analysis and understanding of genetic, transcriptomic and proteomic data obtained from treatment-naïve MM patients, as well as those who have become resistant to thalidomide, lenalidomide and pomalidomide.