In kidney disease, the Wnt/β-catenin signaling pathway acts as an inducer of tubulointerstitial fibrosis by upregulating the expression of profibrotic factors such as fibronectin, fibroblast-specific protein-1, snail-1, matrix metalloproteinase-7, plasminogen activator inhibitor-1, and the components of the renin-angiotensin system [21]. This evidence concerns the gene REN and kidney disorder.