A total of 582 cases with at least 5 years survival time had their primary cancer treated with chemotherapy, and clear evidence of worse survival was still observed in ER+HER2− ILC compared to ER+HER2− IDC (HR: 1.60, 95% CI: 1.05, 2.44) from the multivariate Cox proportional-hazards regression analysis (Table S4). The gene discussed is ERBB2; the disease is cancer.