In this context, a CRFR1-mediated CRC promoting pathway has also been described in CRC cells through modulation of IL-6/JAK2/STAT3 signaling and VEGF-induced angiogenesis [29], while CRFR1 hypermethylation in breast cancer models has been associated with the expression of steroid hormone receptors, a favorable prognostic factor [34]. This evidence concerns the gene STAT3 and breast cancer.