MMP2 and melanoma: The antiproliferative effect of chrysin has been reported in various cancer cell lines including melanoma cell lines, namely human A375 and A375.S2 and murine B16-F1 [28,29], A431 human epidermoid carcinoma cells [30], and the CT26 colon cancer cell line [28,31] have shown that chrysin inhibits MMP-2 activity and at concentrations lower than the lethal concentration, chrysin inhibits cell mobility, migration, and the invasion of cancer cells when analyzed using wound healing and Transwell filter assay.