The antiproliferative effect of chrysin has been reported in various cancer cell lines including melanoma cell lines, namely human A375 and A375.S2 and murine B16-F1 [28,29], A431 human epidermoid carcinoma cells [30], and the CT26 colon cancer cell line [28,31] have shown that chrysin inhibits MMP-2 activity and at concentrations lower than the lethal concentration, chrysin inhibits cell mobility, migration, and the invasion of cancer cells when analyzed using wound healing and Transwell filter assay. This evidence concerns the gene MMP2 and squamous cell carcinoma.