We have shown that the recombinant innate immunity protein Tag7 (a.k.a. PGLYRP1) induces TREM-1-dependent signaling, and that Tag7 interaction with human monocytes leads not only to the enhanced expression of genes coding for proinflammatory cytokines but also to the appearance of lymphocyte subpopulations, showing cytotoxic activity against MHC-negative tumor cells [16]. The gene discussed is HLA-C; the disease is neoplasm.