Recently, T-ALL cells have also been implicated in inducing osteoblast apoptosis and impairing haematopoiesis [26] Further study revealed that the mechanism of T-ALL-mediated osteoblast suppression is via aberrant Notch activation, which plays a role in negatively regulating CXCL12 on osteoblasts [27]. The gene discussed is CXCL12; the disease is acute lymphoblastic leukemia.