Furthermore, the manifestation of bone loss in pre-B ALL is different from AML: BCR-ABL1+ pre-B ALL mice have been shown to develop progressive but severe bone loss during leukaemogenesis caused by impaired osteogenesis, coupled with enhanced osteoclastogenesis and bone resorption via excessive production of RANKL by leukaemic cells [35]. Here, TNFSF11 is linked to acute lymphoblastic leukemia.