TGFB1 and neoplasm: Schematically, they can be divided into M1-macrophages with anti-tumour activity, and M2-macrophages (CD163+), which are characterized by a pro-tumour activity through the secretion of several cytokines (IL-1, IL-6, IL-10, Vascular Endothelial Growth Factor VEGF and TGF-β) [35,36].