The 2’,3’-cGAMP, produced by cyclic GMP-AMP (cGAMP) synthase (cGAS) upon sensing the aberrant or self-leaked cytosolic DNA, activates the stimulator of interferon genes (STING) proteins and this leads to the expression of Type I interferon (IFN) and the secretion of other cytokines and chemokines triggering the anti-cancer immune response [19,20,21,22]. The gene discussed is STING1; the disease is cancer.