FANCD2 and ovarian carcinoma: Since both the FANCD2-involved HR pathway and POLQ-mediated Alt-EJ pathway function in repairing DNA DSBs, efforts have been made to investigate the potential synthetic lethality relationship between FANCD2 and POLQ. It was observed in ovarian carcinoma that POLQ depletion hindered the survival of FANCD2-deficient A2780 cells exposed to PARP inhibitors, cisplatin, and mitomycin C [8].