The activation of CB2 signaling by AM 1241 retarded myocardial fibrosis during the post-myocardial infarction phase via accelerating the translocation of the fibrogenesis-associated transcription factor Nrf2 to nucleus and blocking the TGF-β1/Smad3 pathway [43]. The gene discussed is TGFB1; the disease is Myocardial fibrosis.