Indeed, DCL skin biopsies upregulated arginase 1 (ARG1) and spermine synthase mRNAs involved in polyamines biosynthesis concerning localized cutaneous leishmaniasis (LC) and MCL lesions, highlighting the significance of host ARG1 and arginine transporter (cationic amino acid transporter, CAT2) in MCL [49]. The gene discussed is SLC7A2; the disease is laryngotracheoesophageal cleft.