Indeed, DCL skin biopsies upregulated arginase 1 (ARG1) and spermine synthase mRNAs involved in polyamines biosynthesis concerning localized cutaneous leishmaniasis (LC) and MCL lesions, highlighting the significance of host ARG1 and arginine transporter (cationic amino acid transporter, CAT2) in MCL [49]. Here, SMS is linked to laryngotracheoesophageal cleft.