Over the last 15 years, the identification of a direct association between ALK2/ACVR1 and human disorders, including FOP, DIPG, DISH, CHD, and PFH, has led to extensive research in basic, clinical, and translational medicine concerning this receptor, and various in vitro and in vivo experimental models have been developed to understand the functions of ALK2/ACVR1 and to reveal the molecular mechanisms of the pathogenesis of related disorders. The gene discussed is ACVR1; the disease is coronary artery disorder.