To this end, humanized monoclonal antibodies VGX-100 and IMC-3C5 that target the Vascular endothelial growth factor C (VEGFC)/VEGF receptor 3 (VEGFR3) pathway essential for lymphangiogenesis, are undergoing clinical evaluation as novel cancer therapeutics (NCT01514123 and NCT01288989) [6]. The gene discussed is FLT4; the disease is cancer.