Variants of high concern, B.1.1.7 (VOC-202012/01) identified in the U.K.; 501Y.V2 (B.1.351) identified in the South Africa; and P.1 (B.1.1.28.1) identified in Brazil, all have more than 20 mutations in the S protein, raising the concern that both natural infection-derived immunity as well as vaccine-derived immunity may fail to confer protection against a SARS-CoV-2 variant (re)infection [15,21]. Here, PROS1 is linked to infection.