Mutual mapping of the spot clusters identified in the LGG-SOM (Figure 3) and the ‘all-glioma’ SOM (Figure 2) revealed mostly one-to-one correspondence (Figure S10), except spots F and I, which transform into more diverse gene distributions, presumably due to different cellular compositions in IDH-wt and IDH-mut subtypes, as suggested by maps of single-cell transcriptomic signatures (Figure S11) for IDH-mut gliomas [66] and PA [67]. Here, IDH1 is linked to glioma.