Gene set analysis shows that a series of immunity-related functions activate in PA and E3 (and, to a lesser degree in CL and MES) but are downregulated in IDH-O/E6, while proliferation-related functions are upregulated in GBM-like (and, to a lesser degree in IDH-O) gliomas (Figure 2C and Supplementary File 1: Figures S1–S4 for details). This evidence concerns the gene IDH1 and central nervous system cancer.