CD4 and cancer: GBM-like (CL, MES, and to a lesser degree PN gliomas) show relative high mutational load compared with LGG, presumably causing increased generation of neoantigenes [47], which, in turn, increases tumor immunogenicity and possibly induces infiltration of CD4+ and/or CD8+ T cells, as found in GBM [48,49], LGG [24], and other cancers [50] and seen as specifically increased expression of neoantigene signatures in GBM-like tumors (Figure S4).