In the dominant form, CPVT1 is caused by mutations in the RyR2 gene, encoding the cardiac intracellular Ca2+ release channel (ryanodine receptor 2), the main Ca2+ release channel of the sarcoplasmic reticulum (SR) [5]. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia 1.