In addition, aberrant expression of Dsg3 is also reported in basal cell carcinoma (BCC) where its expression correlates with Dsg2 at the mRNA level but differ greatly at the protein level, with the loss of coordination of DSG2 and DSG3 expression and a reduction of DSG3 in BCC [62,63]. The gene discussed is DSG2; the disease is basal cell carcinoma.