HADHB and proteostasis deficiencies: We also identified proteins with relevance in proteinopathies in MCF-7 cells, including Poly(U)-binding-splicing factor PUF60 (PUF60), associated with amyotrophic lateral sclerosis (ALS) [42,43,44], Transaldolase-1 (TALDO1), associated with Parkinson’s disease [45], and hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta (HADHB), related to Creutzfeldt-Jakob disease [46].