CCNA2 and ovarian cancer: For instance, it has been shown that it inhibits ovarian cancer cells’ colony formation and proliferation by inducing cell cycle arrest, accompanied by the downregulation of cyclins A, B, and E. Minocycline affects ovarian cancer cells through the suppression of IL-6 expression, modulation of the IL-6 receptor system, and suppression of TGF-β1-TAK1-IκB signaling pathway [61,62,63].