Indeed, it has been suggested that EKSs-evoked ketosis may alter the activity of different downstream signaling pathways (e.g., AMPK-, SIRTs- and mTOR-modulated pathways) and modulatory effects, through which not only senotherapeutic drugs, but also ketosis (βHB) can improve symptoms and delay development of age-related hallmarks, age-associated neurodegenerative diseases and learning and memory dysfunctions, and extend lifespan. This evidence concerns the gene MTOR and neurodegenerative disease.