Moreover, activation of SIRT1 generated protective influences in mouse models of amyotrophic lateral sclerosis (e.g., enhanced biogenesis of mitochondria and suppressed deterioration of motor neurons) [94,368,369], preserved dopaminergic neurons in a mouse model of Parkinson’s disease [370] and evoked protection against Aβ plaque formation in mouse models of Alzheimer’s disease [94,371] likely via, for example, SIRT1/PGC1-α/MnSOD pathway [173,372]. Here, PPARGC1A is linked to Alzheimer disease.