In fact, it has been demonstrated that PGC1-α-deficiency may be in connection with neurodegenerative lesions [373], and decreased PGC1-α expression may be one of the most important factors in the development of both Parkinson’s disease [374,375] and Alzheimer’s disease [174,376]. Here, PPARGC1A is linked to hyperinsulinemic hypoglycemia, familial, 4.