PARP1 and early-onset autosomal dominant Alzheimer disease: As it was demonstrated, Aβ and α-synuclein accumulation may generate activation of PAPR1 via, for example, increased level of ROS; thus, enhanced PARP1 activity aggravates Alzheimer’s disease and Parkinson’s disease symptoms by promotion of Aβ and α-synuclein aggregation, respectively [145,149].