SIRT1 and early-onset autosomal dominant Alzheimer disease: It was also demonstrated that caloric restriction can attenuate Alzheimer’s disease progression, for example, by decreasing the accumulation of Aβ plaque [92] and promote longevity and healthy aging [93] likely via SIRT1 activation [93,94,95], whereas higher caloric intake may increase the risk of the development of Alzheimer’s disease [96].