As mTORC1 is able to inhibit autophagy (e.g., mitophagy or macroautophagy of altered proteins) all of drugs or interventions, which are able to inhibit mTORC1 (e.g., caloric restriction leading to mTOR inhibition) may be potent delayer of aging processes and enhancer of lifespan via inhibition of inflammation [180] (Figure 1), by which can alleviate not only neuroinflammation, but also neurodegeneration and related diseases, such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis [183,189]. Here, MTOR is linked to early-onset autosomal dominant Alzheimer disease.