Anti-tissue factor ADCs and MGC018 (targeting B7-H3) were used in a single PDX model, obtaining the partial remission of tumors in both cases; while ADCs targeting fibroblast-associated antigens LRRC15 and FAP, ABBV-085 and FAP5/DM1-DM4, respectively, showed only the tumor-growth inhibition of xenografts derived from commercial established HNC cell lines. The gene discussed is LRRC15; the disease is neoplasm.