HSV1716 OVT has been demonstrated to reduce tumor growth and provide survival advantage as well as to induce significant tumor infiltration of inflammatory immune cells, including CD4+ T cells, CD8+ T cells, NK cells and macrophages in mouse models of intracranial M-3 S91 Cloudman melanoma, 4T1 breast, and rhabdomyosarcoma cancers [48,49,50]. This evidence concerns the gene CD8A and neoplasm.