However, stepwise cox proportional regression analysis showed that only ER-negative receptor (HR = 2.44 (95%CI = 1.33–4.47); p = 0.004) and large tumor size (HR = 2.19 (HR = 1.21–3.98); p = 0.01) were the only variables that independently affected DFS. This evidence concerns the gene ESR1 and neoplasm.