Additional analyses, with adjustments for antidiabetic medications and multimorbiditiy, that includes conditions which are associated with the use of glucocorticoid medications (i.e., chronic obstructive pulmonary disease, rheumatoid arthritis, and gastrointestinal disorders), insulin treatment, and lipid lowering drugs (e.g., Statins), did not alter the observed results (data not shown). The gene discussed is INS; the disease is digestive system disorder.