NR1H4 and metabolic dysfunction-associated steatotic liver disease: Elevated lithocholic acid (LCA) and deoxycholic acid (DCA) in mice feces [23,24] by gut bacteria are well-known to increase intestinal barrier permeability [25] and decrease the expression of hepatic farnesoid X receptor (FXR) [26], which are early events in the development of NAFLD [27,28,29].