SPP1 and ischemic stroke: The screening panel comprised D-dimer, osteopontin (OPN) and osteoprotegerin (OPG), which have previously been associated with cardioembolic and atherosclerotic stroke etiologies [8,12]; the glial fibrillary acidic protein (GFAP), an astrocyte marker that is increased in the hemorrhagic stroke subtype [7]; the von Willebrand factor (vWF), and a disintegrin and a metalloproteinase with a thrombospondin type I motif, member 13 (ADAMTS13), which are known markers of hemostasis and have been linked to the ischemic stroke subtype [13].