Moreover, we demonstrated that DDR1 promotes thyroid cancer cell dedifferentiation and the acquisition of a stem-like phenotype by enhancing the IGF-2/IR-A autocrine signaling loop [9,10] and plays a critical role in promoting bladder cancer cell motility by linking the IGF1R and IR-A to the regulation of F-actin cytoskeleton dynamics [15]. This evidence concerns the gene DDR1 and thyroid cancer.