The present data revealed that TNFR1 signaling was modulated by an overexpressed feedback loop of CFLAR and cIAP2, and its downstream effect was executed by an increased expression of target chemokines (i.e., CCL2, CCL19, CXCL2), cytokines (IL6, LIF) and vascular endothelial growth factors (VEGFC) in DVT samples. Here, CXCL2 is linked to deep vein thrombosis.