IL1B and major depressive disorder: In female subjects with MDD, the levels of IL-1β (MDD, 0.5555 ± 0.3033 pg/mL, vs. female HC, 0.3455 ± 0.2777 pg/mL, p = 0.0355, Figure 2A), IL-6 (MDD, 1.064 ± 0.5719 pg/mL, vs. female HC, 0.7237 ± 0.3694 pg/mL, p = 0.0355, Figure 2B), and CRP (MDD, 790.8 ± 632.4 ng/mL, vs. female HC, 415.2 ± 361.5 ng/mL, p = 0.0497, Figure 2C) significantly increased in the serum compared with those in the female HC group, but not in the male group.