EGFR and familial pancreatic carcinoma: On the other hand, Gene 33 seems to mediate the anti-metastatic function of N-Myc downstream-regulated gene 1 (NDRG1) in pancreatic cancer, as increased expression of NDRG1 posttranscriptionally stabilizes Gene 33, thereby inhibiting EGFR-dependent metastasis by promoting lysosomal degradation of EGFR [67].