Having analyzed the distribution of pathogenic variants and VUS by cancer site we found that pathogenic variants of BRCA1 and BRCA2 were present only in ovarian and breast tumors, and those of other genes were present in four different organs (ovary: 1, breast: 1, endometrium: 1 and digestive tract: 2), whereas VUS were present in all cancer sites (Figure 2E). Here, BRCA1 is linked to cancer.