However, when these significant markers were combined with PD-L1 IHC expression in a single multivariate analysis with the same covariates, the only tumor-related protein found to have a significant association with the risk of progression in patients was MUC16; it was found at levels significantly above the median (HR = 2.01, CI = 1.26–3.20, p = 0.004; Figure 5A). This evidence concerns the gene MUC16 and neoplasm.