As a result, the transcriptional repression exerted by the DDX5/PRC2/HOTAIR complex is impaired, leading to the transcriptional reactivation of PRC2/HOTAIR target genes, including EpCAM and other cellular genes expressed in hepatic cancer stem cells (hCSC) [37], as well as to an increase in HBV cccDNA transcription and HBV replication [37]. This evidence concerns the gene HOTAIR and liver cancer.