Furthermore, the interaction of ANRIL, the lncRNA that displays the highest expression in HBV-related HCC tissues [50], with both EZH2 and SUZ12 guides PRC2 to the Kruppel-like factor 2 (KLF2) promoter, leading to an increase of H3K27 tri-methylation as well as decreased transcription and cell proliferation [52]. This evidence concerns the gene EZH2 and hepatocellular carcinoma.