However, it is unclear whether physical activity levels affect the relationship between the obesity-related traits and genetic variation in FABP2. Accordingly, the aim of the present study was to investigate the influence of the Ala54Thr polymorphism on post-training changes of selected body mass and body composition measurements, as well as with biochemical parameters of energy metabolism. The gene discussed is FABP2; the disease is obesity due to melanocortin 4 receptor deficiency.