Over expression of DJ-1 represses autophagy by inhibiting the conversion of LC3-I to LC3-II as shown in A549 (adenocarcinoma human alveolar basal epithelial cell lines) and H1299 (p53 deficient cell line), HeLa cells, HEK293, and the neuroblastoma cell line SHSY5Y [66]. Here, PARK7 is linked to neuroblastoma.