PARK7 and neuroblastoma: The absence of DJ-1 combined with the presence of these neurotoxins results in increased susceptibility to oxidative stress-induced apoptotic cell death; these findings have been replicated in multiple studies in dopaminergic neurons, cortical neurons, cerebellar granule neurons, neuro-2A (mouse neuroblastoma cell line), SHSY5Y (human neuroblastoma cell line), primary microglia, BV-2 (microglial cell line), and astrocytes [7,24,52,68,69,70].