PARK7 and aortic valve stenosis: In novel data generated for this review using a patient population recently described [105] and methodology available online, we show that thoracic aortic wall DJ-1 expression is decreased in 35 patients (28 male and 7 female; mean ± SEM age 65 ± 10.2 years) undergoing replacement for an ATAA compared to thoracic aortic DJ-1 expression in 31 (18 male and 13 female; mean age 64.6 ± 11.5 years) patients with normal ascending thoracic aortic diameter undergoing aortic valve replacement for severe aortic valve stenosis (AVS) (Figure 4A).