In the afore-mentioned case of the 12-year old girl, DNA sequencing analysis of the ABCG2 gene revealed the presence of heterozygously expressed missense (c.393G > T, p.M131I) and nonsense (c.706C > T, p.R236X) mutations (Figure 1, blue residues) causing the pediatric-onset of hyperuricemia observed in the girl`s ancestry and the early-onset of gout especially in male individuals of the maternal line of inheritance. Here, ABCG2 is linked to hyperuricemia.