BAG6 and B-cell chronic lymphocytic leukemia: The same authors have also demonstrated that BAG6, when expressed on the surface of exosomes, is able to activate NK cell cytotoxicity, suggesting that exosomal BAG6 can represent a component of “induced self-activation” of NK cells and that a dysregulated balance of exosomal vs. soluble BAG6 expression may cause CLL evasion from NK cells [148].