HLA-G and B-cell chronic lymphocytic leukemia: It has also been reported that NK cells from CLL patients, particularly those with advanced disease, overexpress the ILT2/CD85j inhibitory receptor [178,179], while CLL cells abnormally express its ligand HLA-G, which has been found to be associated with poor prognosis and to suppress NK cell-mediated cytotoxicity [149,179,180].