Conversely, a weak decrease in the expression of KIR2DL1, which recognizes group-2 HLA-Cw alleles, has been found in CLL patients with an unfavorable prognosis [34], and this association is probably due to the higher frequency of its ligand HLA-Cw*06 in CLL cohorts than in healthy controls [176,177]. The gene discussed is KIR2DL1; the disease is B-cell chronic lymphocytic leukemia.