Conversely, Costello et al. found that expression levels of NKp30, NKp40 and NKp46 are similar in NK cells of CLL patients and healthy donors, but analysis of different groups of CLL patients showed that lower levels of NKp30 and NKp44 are associated with poor prognostic factors [35]. This evidence concerns the gene NCR2 and B-cell chronic lymphocytic leukemia.