JAK1 and myeloproliferative disorder: In this study, we expanded our previous research by examining the mechanism of IL-6 induction of angiogenic factors via proliferation-related JAK1/2, PI3K, and mTOR signaling in JAK2V617F positive HEL cells and mononuclear cells (MNC contains lymphocytes (T cells) and monocytes) of patients with MPN.