CDH2 and pachyonychia congenita: Additionally, we also observed the downregulation of mesenchymal markers, i.e., N-cadherin, no effect on the expression of epithelial marker E-cadherin, and claudin-1 in COLO 357 and SW1990 cells treated with Nic (5 μM and 10 μM) (Supplementary Figure S2B) leading to inhibition of migration potential of PC cells.