NFKB1 and central nervous system cancer: The anti-cancer activity of Nic is associated with the inhibitory effects on multiple intracellular signaling pathways such as Wnt/β-catenin signaling (adrenocortical carcinoma, ovarian cancer, glioma, colorectal, breast, head and neck, and renal cell carcinoma) [16,17,18,19,20,21,22], JAK/STAT pathway (lung cancer and colon cancer) [23,24] and mTORC1, Notch, NFκB signaling pathways (cervical, colon, glioma, and leukemia) [25,26,27].