Among the last two of the analyzed most upregulated genes between differentiated osteoblasts and day 1 ASC culture, KANK3 was linked to cancer processes as a tumor suppressor gene, while MMP27 was already detected to be upregulated after long-term in vitro culture, suggesting its overexpression is not directly connected to the differentiation process [62,63]. This evidence concerns the gene MMP27 and neoplasm.