KLRK1 and cancer: Interestingly, Entinostat enhanced NK cell-mediated killing of tumors through both induction of MICA/B on target cells and NKG2D up-modulation on NK cells in a cancer study [34], hence the impact of Entinostat on the NKG2D/NKG2DL pathway in the context or NK cell clearance of reactivated HIV is worth being investigated in future work.