EBV patient’s negative cells often have lymph node metastases (N1–N3) and have low expression and production of PD-L1 (Figure 3C), on the other hand, EBV-positive patients frequently did not have lymph node metastasis (N0) and have high expression and production of PD-L1 (p < 0.001) (Figure 3D). This evidence concerns the gene CD274 and metastatic malignant neoplasm in the lymph nodes.