Consistent with a minimal impact of Rb treatment in enhancing NP396–404-specific CD8 T cells following acute LCMV-Arm infection, no alteration in the number of IFNγ-producing NP396–404-specific CD8 T cells was observed in Rb treated LCMV-Arm infected CD4−/− mice (Figure 3A). This evidence concerns the gene IFNG and infection.